Endocrine Abstracts

Introduction: CD56 (neural cell adhesion molecule/NKH1/LEU19 and LEU7/NHK-1) is an antigen related to follicular epithelium differentiation.Materials and methods: We evaluated the expression of CD56 protein in normal follicular thyroid tissue, 15 non-neoplastic thyroid lesions (nodular hyperplasia–NH, Graves–Basedow disease (GB) and chronic lymphocytic/Hashimoto is thyroiditis (HT) and 38 thyroid neoplasias derived from follicular cells (25 PTC...

Introduction: Acromegaly is a rare disease caused by excess production of growth hormone (GH) and is associated with multiple complications. The prevalence of associated complications and the mortality rate are associated with the duration of exposure to elevated GH levels, early diagnosis being imperative. Diagnosis of acromegaly is most frequently late, after several years of evolution, with the development of cardiovascular, respiratory, metabolic complications. The presenc...

Introduction: Gigantism represents a rare pathology in children, characterized by growth hormone (GH) excess, before epiphyseal fusion. It associates significant morbidity and decreased life expectancy, in lack of appropriate treatment.Case presentation: O.D., a male patient, 16 years old now, has been followed in our clinic since 2016, being diagnosed with gigantism in Bega Pediatric Clinic, at the age of 12 years 9 months. In 2014, the patient presente...

Introduction: Acromegaly is a debilitating, indolent disease that develops over several years due to extended exposure to elevated growth hormone (GH) levels. It is most commonly caused by somatotropinomas. It represents a rare pathology with an incidence of 3–14 cases per 1 million inhabitants and a prevalence of 40 to 90 cases per 1 million inhabitants. Pituitary adenomas respresent a challenging disease in young patients. Transphenoidal surgery is the best therapeutic...

Background: Acromegaly is a chronic rare disease induced by persistent hypersecretion of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) in adult patients. Several studies have associated acromegaly with an increased risk for developing different benign or malignant tumors.Case presentation: A 33-year old female patient was diagnosed with acromegaly due to a large pituitary macroadenoma, in 2009. In the same period, she was also diagnosed wi...

Introduction: Osteoprotegerin (OPG) and receptor activator for nuclear factor-κB ligand (RANKL) are cytokines that increase in cardiovascular diseases. Serum OPG levels are high in vascular calcifications, while RANKL is expressed by atherosclerotic lesions. The aim of the study was to assess the OPG and RANKL concentrations in patients with stable coronary artery disease.Material and methods: The study included 38 patients diagnosed with ischemic c...

Introduction: Polycystic ovary syndrome (PCOS) is associated with a complex altered hormonal profile. Functional mild hyperprolactinemia can be found in up to 25–30% of PCOS women. The aim of the study was to determine the incidence of hyperprolactinemia in PCOS patients and to correlate the prolactin values with hormonal and metabolic data.Material and methods: The study included 25 women, diagnosed with PCOS, according to Rotterdam criteria (mean ...

Introduction: In the interpretation of the thyroid tests in a patient treated chronically with amiodarone (AMD), the effects on the thyroid should be considered. The aim of the study was to evaluate the thyroid parameters in amiodarone-induced thyrotoxicosis (AIT), compared to endogenous hyperthyroidism.Materials and methods: The study group included 36 patients with AIT (mean age 57.6±7.8 years, 11 women (F), 25 men (M)). The mean duration of AMD-t...

Background: Whereas many papers have reported on clinical and morpho pathological features of thyroid cancer with BRAFV600E mutation, a limited number of studies have been focused on the quantification of BRAF mRNA expression in thyroid tumors.The present study aimed to assess the expression of BRAF transcript in fine needle aspiration specimens, prelevated from cases with nodular thyroid disease.Material and methods: Th...

Introduction: Thyroid follicular adenomas (FA) and adenomatous nodules (AN) – lesions frequently found in areas with iodine deficiency, can be normo-/hypofunctioning (scintigraphically cold – SCN) or hyperfunctioning (scintigraphically hot – SHN) nodules.Aim: Evaluation of proliferation potential in thyroid nodules on tissue samples obtained at surgery from euthyroid patients clinically diagnosed with SCN and from patients with thyroid hyp...